Ronaldsway Airport's runway has been closed by heavy ice and sleet.
The airport is asking passengers to be patient as teams carry out de-icing work.
It adds normal operations will resume as soon as it's safe, and to check for flight updates via the airport's website.
A yellow weather warning for snow and ice is currently in place until midday, Friday, January 2.
Yellow weather warning remains in place
Women's worldwide motorbike relay event this month
Cartoonist shows off Isle of Man scenes
Tynwald to consider pay rise for election officials
Capital gets Xmas tree recycling scheme
MHK calls for strong cultural identity
Charity rehomed almost 300 cats last year
Take care on the roads, say police