Police say the Mountain road could be shut until at least 7pm after a serious crash.
Officers say the incident means the route will be closed between Barrule Park and the Bungalow.
They say someone's suffered serious injuries in the crash.
No further details have yet been released.
Applications open for fee school meals
The government says applications for free school meals are now open.
MHK to ask about school suspension numbers
School suspensions will be on the agenda for Tynwald members next week.
Manx stamps crashed on moon because of instrument problems, says company
Problems with precision instruments and recognising craters led to a lunar lander carrying digitised Manx stamps crashing on the moon, according to the company behind the mission.
Film version of Sam Barks stage musical Frozen out next month
The latest movie to star Manx actress Samantha Barks will be out next month.
Would the UK save us during a digital war?
Can the Island fend off hackers by itself during a major cyber-attack?
First - and most-devoted - German fans arriving for TT!
One of the Island's best-known unofficial TT campsites is back - with more than a week to go to before the festival begins!
Don't get caught out by pet travel rule changes!
The government is urging pet-owners travelling to Northern Ireland this summer to read up on new rules.
Minister hopes to save £800,000 out of government's £1.3 billion budget
Minister without Portfolio Tim Crookall says he has identified £800,000 of possible government savings.
