Police say the Mountain road could be shut until at least 7pm after a serious crash.
Officers say the incident means the route will be closed between Barrule Park and the Bungalow.
They say someone's suffered serious injuries in the crash.
No further details have yet been released.
Israelis added to sanctions list over human rights abuses
Two Israelis have been added to the Island's sanctions list in connection with violation of human rights.
Cycling race ready for streets of Castletown
Castletown residents are being reminded to move their vehicles on Sunday as a huge cycling roadrace gets underway.
T-Rex tickets now on sale
Tickets have gone on sale for an attempt to break a prehistoric world record in Peel this summer!
Memorial service for Castletown teen
A memorial service for a Castletown teenager who died during an incident in Ramsey last month will be held this week.
Liverpool yacht race finishes in Douglas today
Yachts from Merseyside will be arriving in Douglas today at the end of an annual race.
Commissioners give Ramsey some TLC
Ramsey Commissioners say workers have been out and about this week making sure the town looks its best.
Suspected chemical munition means Derbyhaven remains closed
Experts from the UK will assess a chemical incident at Ronaldsway airport today.
Roads closed and bus routes changed for Parish Walk today
One of the Island's biggest annual sporting events is underway today.
