The accident happened last night (Wednesday) at Ballacobb near Ballaugh.
The Fire & Rescue Service said the incident involved one car which had rolled onto its roof.
The occupants were free of the car when the fire service arrived.
They were treated at the scene by paramedics before being taken to hospital.
Police closed the road for several hours after the crash which happened at around 20:00.
Castletown Living Streets scheme 'paused', says minister
Infrastructure Minister Michelle Haywood says a scheme to improve Castletown's streets has been put on hold.
Cregneash buses to be raised in Keys
A bus route to one of the Island's beauty spots will be raised in the House of Keys next week.
Second Mountain Road closure today after spill
The Department of Infrastructure says it needs to close the Mountain Road tonight as it resurfaces more than 200 metres.
Commissioners unveil detailed plans for 260-person venue on promenade
Peel commissioners have unveiled detailed plans for a huge new venue near the town's bowling greens, which could hold up to 260 people and 10 staff.
Liverpool agreement didn't hand anything to Merseyside, says chief minister
Chief Minister Alf Cannan says an agreement signed with Liverpool is a way to learn from each other.
What would make you visit Douglas more often?
An organisation which promotes and helps the Island's capital is asking for your views.
Commissioners announce wildflower scheme in Ramsey
Ramsey commissioners say they'll show their commitment to the environment by not mowing the grass.
43 calls to police over parking this year
Home Affairs Minister Jane Poole-Wilson says she can't give figures for how many parking offences there have been - because many aren't dealt with by police.
